Evidence map›Paper›PMID 42269604›Full record

ArticleCell2026

Persistent and transient senescent cells contribute to brain-barrier development.

L Ashley Watson, Zoe Adelsheim, Mackenzie J Carter, Grace T Carter, Karen L Jimenez-Reyes, Huijie Du, Ziqing Zhu, David B Berry, Mia C Paredez, Rania H Palaniappan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

L Ashley WatsonDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Zoe AdelsheimDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Mackenzie J CarterDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Grace T CarterDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Karen L Jimenez-ReyesDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Huijie DuDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Ziqing ZhuDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
David B BerryDepartment of Orthopedic Surgery, University of California, San Diego, La Jolla, CA, USA.
Mia C ParedezDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Rania H PalaniappanDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
John M AugustineDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Hiruy S MeharenaDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA; Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA. Electronic address: hmeharena@ucsd.edu.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Nuclear-Metabolic Interplay in Down syndromeR01HD115635 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hiruy Sibhatu Meharena · 2024 to 2026
$2.0M
Equipment upgrade for 7T Small Animal MRI systemS10OD032343 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIU, THOMAS T · 2022 to 2022
$600k
NCI NIH HHS P30 CA023100NICHD NIH HHS R01 HD115635NIDDK NIH HHS P30 DK063491NIH HHS S10 OD032343
6 · The paper itself

Abstract

Establishment of the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier requires precise coordination between diverse cell types to protect and nourish the brain. Here, we identify developmentally programmed p21

Indexed as

Blood-Brain BarrierCellular SenescenceAnimalsBrainChoroid PlexusEndothelial CellsEpithelial CellsFemaleMacrophagesMiceMice, Inbred C57BLblood-brain barrierblood-cerebrospinal fluid barrierbrain developmentbrain-resident macrophageschoroid plexussenescencevascular endothelial cells

Identifiers

PMID42269604
PMCPMC13309908

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.