Evidence map›Paper›PMID 42269513›Full record

ArticleMolecular pharmacology

Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function.

Arya Y Nakhe, Jordyn R Dobson, Prasanna K Dadi, David Westover, Emily L Days, Paige Vinson, C David Weaver, Jerod S Denton, Spencer J Peachee, Soma Behera and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arya Y NakheDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Jordyn R DobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
David WestoverHigh-Throughput Analytics, Analytical Research and Development, Merck & Co. Inc., Rahway, New Jersey.
Emily L DaysVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.
Paige VinsonHigh-Throughput Screening Center, Southern Research, Birmingham, Alabama.
C David WeaverDepartment of Chemistry, Department of Pharmacology, and Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.
Jerod S DentonDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Spencer J PeacheeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Soma BeheraDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Shannon E GibsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Valentina A Rodriguez Da SilvaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Amit SelaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee. Electronic address: david.a.jacobson@vanderbilt.edu.

Funding

MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Initiative for Maximizing Student Development (IMSD) at VanderbiltT32GM139800 · NIGMS · VANDERBILT UNIVERSITY · PI RHOADES (STERLING), JULIE A, SEREZANI, C. HENRIQUE · 2021 to 2025
$3.7M
Two-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3M
Molecular Mechanisms Regulating Pancreatic Delta Cell Function and DysfunctionR01DK129340 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2022 to 2026
$2.3M
Secretagogue and Gi/o-GPCR signaling through the islet Na+/K+-ATPase in health and diabetesR01DK136768 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2023 to 2026
$2.0M
NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK129340NIDDK NIH HHS R01 DK136768NIDDK NIH HHS T32 DK007563NIGMS NIH HHS T32 GM139800NIH HHS DK097392NIH HHS DK129340NIH HHS DK129340-S1NIH HHS DK136768
6 · The paper itself

Abstract

The two-pore domain K

Indexed as

Insulin-Secreting CellsPotassium Channel BlockersPotassium Channels, Tandem Pore DomainSmall Molecule LibrariesAnimalsCalciumGlucoseHumansInsulinInsulin SecretionCalciumGlucoseInsulinPotassium Channel BlockersPotassium Channels, Tandem Pore DomainSmall Molecule LibrariesCalciumInsulin secretionIsletKCNK16TALK-1Two-pore domain K(+) channel

Identifiers

PMID42269513
PMCPMC13494105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.