ArticleProceedings (Baylor University. Medical Center)2026
Clinicopathologic features and survival disparities in early onset clear cell renal cell carcinoma in Texas.
Article in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Early onset renal cell carcinoma on the rise.Proceedings (Baylor University. Medical Center) · 2026Article
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Abstract
backgroundEarly onset renal cell carcinoma (EORCC), defined as diagnosis at <47 years, accounts for 3% to 7% of all renal cell carcinoma cases, and the incidence has increased significantly. Up to 82.3% of EORCC cases are clear cell type (EOccRCC). Comprehensive data on the clinicopathologic features and survival outcomes in this subgroup remain limited. This study aimed to investigate the clinicopathologic characteristics and survival patterns of EOccRCC in Texas.
methodsThis cohort study utilized anonymized data from the Texas Cancer Registry to examine cases of EOccRCC. Clinicopathologic features were analyzed, and survival outcomes were assessed using log-rank (Mantel-Cox) tests and Kaplan-Meier survival curve analyses. Patients in different ethnic groups were compared using post hoc pairwise chi-square tests for baseline characteristics, and adjusted hazard ratios of all-cause and cancer-specific mortality with multivariable Cox models were reported.
resultsA total of 4223 EOccRCC cases (age range 5-46 years, mean age 39.7) were identified. The majority of patients were male (60.1%), White (90.7%), non-Hispanic (57.3%), and obese (61.9%). At the time of diagnosis, 76.3% of patients had American Joint Committee on Cancer (AJCC) stage 1 disease and 6.7% had stage 4 disease. By the last follow-up, 13.1% of patients had died, with half of the deaths attributed to ccRCC. Mexican Hispanic ethnicity had a poorer prognosis (
conclusionsEOccRCC trends increased in Texas and showed multiple discrepancies in clinicopathologic features and survival. Mexican Hispanic patients presented with more advanced disease, higher rates of being uninsured, and greater neighborhood poverty level and demonstrated poorer prognosis compared to non-Hispanic and other Hispanic populations.
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