Evidence map›Paper›PMID 42269046›Full record

ArticleProceedings (Baylor University. Medical Center)2026

The rapid surge of colorectal cancer in children and young adults: a 22-year analysis of the CDC WONDER database.

Islam Mohamed, Mohamed Abuelazm, Bashar M Al Zoubi, Ahmed Aref, Fouad Jaber, Dushyant Singh Dahiya, Hazem Abosheaishaa, Maya Mahmoud, Nikki Duong, Jamal Ibdah and 1 more

Abstract read
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In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The shifting birth cohort.Proceedings (Baylor University. Medical Center) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Islam MohamedDepartment of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0002-0740-8960
Mohamed AbuelazmDepartment of Internal Medicine, University of Tanta, Tanta, Egypt.
Bashar M Al ZoubiDepartment of Medicine, Hashemite University, Zarqa, Jordan.
Ahmed ArefDepartment of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.
Fouad JaberDepartment of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA.
Dushyant Singh DahiyaDepartment of Gastroenterology and Hepatology, University of Kansas, Kansas City, Kansas, USA.
Hazem AbosheaishaaDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Maya MahmoudDepartment of Gastroenterology, St. Louis University, St. Louis, Missouri, USA.
Nikki DuongDepartment of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.
Jamal IbdahDepartment of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
Hassan GhozDepartment of Gastroenterology and Hepatology, University of Maryland, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly onset colorectal cancer (EO-CRC) is rising globally. We analyzed 22 years of US data to identify specific age, gender, and racial/ethnic groups at highest risk.

methodsUsing the CDC WONDER database (1999-2020), we analyzed CRC incidence in individuals aged 10 to 44. Trends were quantified via annual percentage change (APC) and average annual percentage change (AAPC) using Joinpoint Regression (v.5.0.2).

resultsThe 10- to 14-year age cohort exhibited the most pronounced increase (AAPC 11.25%;

conclusionThe sharp escalation of CRC in pediatric and adolescent populations signals a public health crisis, necessitating increased clinical vigilance and investigation into early life environmental drivers.

Indexed as

Colorectal NeoplasmsAdolescentAdultCenters for Disease Control and Prevention, U.S.ChildDatabases, FactualFemaleHumansIncidenceUnited StatesYoung AdultAdolescentcolonearly onset colorectal cancermalignantyoung adult

Identifiers

PMID42269046
PMCPMC13271338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.