Trimeric hemagglutinin vaccine provides chickens complete protection against lethal H5 subtype avian influenza virus from clade 2.3.4.4b.

Taoran Chen, Qiao Huang, Xingtao Chen, Jiahang Zhu, Deming Kong, Xiuying Liao, Ming Liao, Huiying Fan

Abstract read

In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Taoran ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Qiao HuangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Xingtao ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Jiahang ZhuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Deming KongCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Xiuying LiaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Ming LiaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Huiying FanCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

H5 subtype highly pathogenic avian influenza virus (HPAIV) of clade 2.3.4.4b has prevailed globally, causing economic losses in the poultry industry and posing zoonotic threats. While inactivated vaccines are advantageous tools for prevention and control, their reliance on egg-based production and live viruses necessitates safer alternatives. Based on multiple design strategies, including signal peptide replacement, transmembrane domain truncation, fusion with Trimer-tag or

Indexed as

Hemagglutinin Glycoproteins, Influenza VirusInfluenza A virusInfluenza in BirdsInfluenza VaccinesPoultry DiseasesAnimalsAntibodies, ViralChickensHEK293 CellsHumansProtein Subunit VaccinesAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesProtein Subunit VaccinesCHO cellclade 2.3.4.4bH5 subtypehighly pathogenic avian influenza virustrimeric hemagglutinin

Identifiers

PMID42269026

DOI10.1080/22221751.2026.2678649

PMCPMC13255209

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.