ArticleScience advances2026
Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult neurogenesis sustains olfactory function, facilitates the acquisition of new memories, and provides resilience against depression in mice. Neural stem cells (NSCs) elicit selective responses to different physiological and pathological stimuli, thereby modulating neuron production. Here, we show that fear conditioning stimulates neurogenesis in the adult mouse brain septum by activating NSCs in the dorsal septum (dsNSCs) situated near a plexus of serotonergic axons originating from raphe nucleus neurons-key regulators of mood, anxiety, and stress responses. Elevation of serotonin (5HT) levels with the antidepressant and anxiolytic drug fluoxetine similarly promoted dsNSC proliferation and neurogenesis. The adult-born GABAergic interneurons integrate into septal nuclei. These findings suggest a potential adaptive response in mice to stress-inducing aversive experiences and elevated 5HT in the adult septum.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.