Evidence map›Paper›PMID 42268975›Full record

ArticleScience advances2026

Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome.

Yan Li, Ashley G Anderson, Guantong Qi, Sih-Rong Wu, Jean-Pierre Revelli, Hu Chen, Zhandong Liu, Huda Y Zoghbi

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yan LiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1656-3452
Ashley G AndersonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9650-1130
Guantong QiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Sih-Rong WuDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Jean-Pierre RevelliDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4789-3104
Hu ChenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0001-5472-7158
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-7608-0831
Huda Y ZoghbiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-0700-3349

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5M
Tecan EVO GenePaint robotS10OD016167 · OD · BAYLOR COLLEGE OF MEDICINE · PI LJUNGBERG, CECILIA · 2013 to 2013
$215k
Examining adult hippocampal neurogenesis and cognitive function in Rett syndromeF32NS122920 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ANDERSON, ASHLEY GRACE · 2022 to 2023
$139k
NICHD NIH HHS P50 HD103555NIH HHS S10 OD016167NINDS NIH HHS F32 NS122920NINDS NIH HHS R01 NS057819
6 · The paper itself

Abstract

Rett syndrome (RTT) is an X-linked neurological disorder caused by

Indexed as

Cell NucleusRett SyndromeTranscriptomeAnimalsDisease Models, AnimalFemaleGene Expression ProfilingHippocampusMaleMethyl-CpG-Binding Protein 2MiceMosaicismMutationSingle-Cell Gene Expression AnalysisMecp2 protein, mouseMethyl-CpG-Binding Protein 2

Identifiers

PMID42268975
PMCPMC13251834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.