In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
Yuwen WangDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0002-7612-7935 Zheng ZhongDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0001-6403-4064 Zeqing LiThe Fourth Affiliated Hospital of Guangzhou Medical University, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China.ORCID 0009-0009-1867-3004 Yuecong GuoCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, New Cornerstone Science Laboratory, National Center for Nanoscience and Technology, Beijing 100190, China.
Christina Sin U IeongDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0009-0005-1512-0974 Tao YaoDepartment of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-8841-0455 Boguang YangDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0003-2142-9319 Ning ZhangDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0009-0001-7867-8028 Songlin HeDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0002-3366-3690 Zhilong ZhouDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Jun LiuDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Runxuan CaiDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0009-0009-0578-5859 Yaling WangCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, New Cornerstone Science Laboratory, National Center for Nanoscience and Technology, Beijing 100190, China.ORCID 0000-0002-5845-5150 Chung Hang Jonathan ChoiDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0003-2935-7217 Chuanbin MaoDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0002-8142-3659 Denghui XieDepartment of Orthopedic Surgery, Center for Orthopedic Surgery, and Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.ORCID 0000-0001-5414-3152 Zhifeng HuangDepartment of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-9613-9423 Bo LiuState Key Laboratory of Advanced Design and Manufacturing Technology for Vehicle, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, Hunan 410082, China.ORCID 0000-0003-1761-8782 Maobin XieThe Fourth Affiliated Hospital of Guangzhou Medical University, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China.ORCID 0000-0001-9082-4510 Chunying ChenCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, New Cornerstone Science Laboratory, National Center for Nanoscience and Technology, Beijing 100190, China.ORCID 0000-0002-6027-0315 Zhong Alan LiDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID 0000-0002-6009-629X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Precise control over stem cell differentiation is of crucial importance in regenerative medicine, such as stem cell-based bone repair. Chiral nanoparticles (NPs) exhibit enantiomer-dependent interactions with stem cells, providing a promising strategy for guiding cell behaviors. Here, we investigated the role of chiral NPs in modulating osteogenic differentiation of stem cells. L-CF-NPs, D-CF-NPs, and A-CF-NPs with controllable nanoscale chirality were synthesized to investigate the effect of enantioselectivity on stem cell fate. In vitro, L-CF-NPs resulted in the highest cellular uptake through clathrin-mediated, integrin-involved endocytosis. This led to the most pronounced up-regulation of osteogenic marker expression, mineralization (via MAPK/JNK/ERK), and angiogenic marker expression. In vivo, volumetric 3D-bioprinted scaffolds incorporating L-CF-NPs resulted in the fastest bone regeneration in a rat model of critical-size bone defects. This work establishes nanoscale chirality as a design parameter for biomaterials, offering a promising approach to regenerating bone and other tissues.
Indexed as
Bone RegenerationCell DifferentiationMesenchymal Stem CellsNanoparticlesOsteogenesisStem CellsAnimalsHumansRatsStereoisomerismTissue Scaffolds
Identifiers
PMID42268950
PMCPMC13251863
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
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