Evidence map›Paper›PMID 42268949›Full record

ArticleScience advances2026

Rpd3L regulates transcription-replication conflict via H3K4 methylation-dependent and -independent chromatin mechanisms.

Shin Yen Chong, Ya-Ling Chen, Yueh-Tzu Hsu, Chia-Ling Hsu, Tsai-Ming Lu, Yi-Chen Lo, Cheng-Fu Kao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shin Yen ChongDepartment of Food Science, National Ilan University, Yilan 260007, Taiwan.ORCID 0000-0002-3452-4596
Ya-Ling ChenInstitute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei 115201, Taiwan.ORCID 0009-0002-6022-2361
Yueh-Tzu HsuDepartment of Food Science, National Ilan University, Yilan 260007, Taiwan.ORCID 0009-0009-3874-0323
Chia-Ling HsuInstitute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei 115201, Taiwan.ORCID 0000-0002-9900-8226
Tsai-Ming LuInstitute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei 115201, Taiwan.ORCID 0000-0001-6416-8193
Yi-Chen LoGraduate Institute of Food Science and Technology, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 106319, Taiwan.ORCID 0000-0002-1426-7852
Cheng-Fu KaoInstitute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei 115201, Taiwan.ORCID 0000-0002-8875-8152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Faithful genome duplication requires coordination between transcription and replication. Disruption of this coordination causes transcription-replication conflicts (TRCs), leading to replication stress and genome instability. How chromatin regulators modulate these processes remains unclear. Here, we show that the Rpd3L histone deacetylase complex dynamically modulates chromatin state to control replication fork progression and buffer TRCs in

Indexed as

ChromatinDNA ReplicationHistone DeacetylasesHistonesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticAcetylationGenomic InstabilityLysineMethylationChromatinHistone DeacetylasesHistonesLysineRPD3 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID42268949
PMCPMC13251831

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.