ArticleProceedings of the National Academy of Sciences of the United States of America2026
Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.
Thomas A Kluiver, Anna Nordin, Yuyan Lu, Xuan Guo, Stephanie A Schubert, Darien Yeung, Arif Ibrahim Ardisasmita, Wessel Terpstra, Chang Zhang, Xiaochen Duan and 9 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
19 authors.
Anna Nordin *Wallenberg Centre for Molecular Medicine, Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0002-5868-4797 Yuyan LuPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Stephanie A SchubertPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Darien YeungPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Arif Ibrahim ArdisasmitaPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.ORCID 0000-0001-8527-4585 Chang ZhangPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Xiaochen DuanPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Rishi SavurPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Marius C van den HeuvelDepartment of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands.
Vincent E de MeijerDepartment of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands.ORCID 0000-0002-7900-5917 Ruben H de KleineDepartment of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands.ORCID 0000-0003-3975-3184 Kathelijne KraalPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Ronald R de KrijgerPrincess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.
Claudio CantùWallenberg Centre for Molecular Medicine, Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0003-1547-5415 Funding
Additional Ventures (AV) SVRF2021-1048003Canadian Institutes of Health Research (CIHR) MFE-200902Cancerfonden (Swedish Cancer Society) 21 1572 Pj 24 3487 PjKIKA 425Oncode Accelerator NGFOP2201Swedish Research Council 2021-03075 2023-01898
6 · The paper itselfAbstract
The mechanisms by which Wnt/β-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiting our ability to target the aberrant cell growth typical of many Wnt-driven cancers. Here, we focus on malignant liver tumors driven by activating
Indexed as
beta CateninLiver NeoplasmsLymphoid Enhancer-Binding Factor 1Transcription Factor 7-Like 2 ProteinWnt Signaling PathwayAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMutationPhenotypeProtein Bindingbeta CateninCTNNB1 protein, humanLEF1 protein, humanLymphoid Enhancer-Binding Factor 1TCF7L2 protein, humanTranscription Factor 7-Like 2 Proteincancernovel motifTCF/LEFWnt signalingβ-catenin
Identifiers
PMID42268900
PMCPMC13273282
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