Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Zhuqing WangSchool of Molecular Biosciences, Washington State University, Pullman, WA 99164.ORCID 0000-0002-3988-0733
Yasuhiro YamauchiYanagimachi Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96822.
Sheng ChenThe Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502.ORCID 0000-0002-2089-3227
Huili ZhengSchool of Molecular Biosciences, Washington State University, Pullman, WA 99164.
Monika A WardYanagimachi Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96822.ORCID 0000-0002-2483-5622
Wei YanSchool of Molecular Biosciences, Washington State University, Pullman, WA 99164.ORCID 0000-0001-9569-9026
Funding
Mechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI ZHENG, HUI · 2019 to 2024
$7.2M
Translational Pilot Project ProgramP30GM131944 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2019 to 2023
$5.9M
Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI YAN, WEI · 2014 to 2018
$5.4M
Do we need Y chromosome for successful reproduction?R01HD072380 · NICHD · UNIVERSITY OF HAWAII AT MANOA · PI WARD, MONIKA A · 2012 to 2022
$3.7M
Epitranscriptomic regulation of spermatogenesis and male fertilityR01HD099924 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YAN, WEI · 2020 to 2024
$1.9M
The roles of mouse Y chromosome Zfy genes in male reproduction.R01HD114645 · NICHD · UNIVERSITY OF HAWAII AT MANOA · PI Monika A Ward · 2024 to 2026
$1.6M
Messenger RNA Fate Control in SpermatogenesisR01HD085506 · NICHD · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2015 to 2019
$1.5M
Are sperm-borne small RNAs important?R21HD071736 · NICHD · UNIVERSITY OF NEVADA RENO · PI YAN, WEI · 2012 to 2013
$380k
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD071736 HD085506 HD098593 HD099924HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD072380 HD114645NICHD NIH HHS P50 HD098593NICHD NIH HHS R01 HD072380NICHD NIH HHS R01 HD085506NICHD NIH HHS R01 HD099924NICHD NIH HHS R01 HD114645NICHD NIH HHS R21 HD071736NIGMS NIH HHS P30 GM110767NIGMS NIH HHS P30 GM131944
6 · The paper itself
Abstract
Paternal epigenetic inheritance remains mechanistically unresolved. Recent studies propose that environmental exposures induce mitochondrial DNA (mtDNA)-dependent transcription in sperm during epididymal transit, altering small RNA content and offspring phenotypes. Here, we show that mature murine sperm are effectively devoid of mtDNA, precluding mtDNA-dependent transcription, and that sperm-borne mitochondrial RNAs originate during spermatogenesis. Testicular sperm transmitted diet-induced metabolic traits as efficiently as, and in most cohorts more efficiently than, epididymal sperm. These findings establish testicular inheritance independent of sperm mtDNA transcription and epididymal exposure.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Testicular origin of epigenetic inheritance independent of sperm mitochondrial DNA and epididymal exposure. · full record | OpenQuestion