ArticleCell reports2026
B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response.
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Maturation of antibody responses entails B cell Aicda/AID and Prdm1/BLIMP-1 expression for SHM/CSR, plasma cell differentiation, and production of class-switched high-affinity antibodies. We determined that TET1, TET2, and TET3 are not expressed in resting naïve B lymphocytes, and only TET2 is induced in differentiating B cells for AID and BLIMP-1 expression. B cell TET2 recruits OGT, a metabolic sensor and sole protein O-GlcNAcylator, for O-GlcNAcylation of itself and chromatin H2B-S112. TET2 O-GlcNAcylation supports TET2-mediated active DNA demethylation (5mC oxidation to 5hmC) of Aicda and Prdm1 loci. This, together with these loci H2B-S112 O-GlcNAcylation, promotes Aicda/AID and Prdm1/BLIMP-1 expression for maturation of T-dependent and T-independent antibody responses. TET2 recruits OGT through its C-terminal-end, as evidenced by Tet2
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