Evidence map›Paper›PMID 42268487›Full record

ArticleAnnals of biomedical engineering2026

Oxygen Transport Impairment in the Failing Heart: A Histology-Image-Based Computational Analysis.

Haifeng Wang, Mythri Tumbalam Gooty, David E Lanfear, Hani N Sabbah, Lik-Chuan Lee

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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haifeng WangDepartment of Biomedical Engineering, Shantou University, No. 243, Daxue Road, Jinping District, Shantou, Guangdong, China. haifeng.wang@rub.de.ORCID http://orcid.org/0000-0001-8786-2479
Mythri Tumbalam GootyDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.
David E LanfearCenter for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, USA.
Hani N SabbahDivision of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, MI, USA.
Lik-Chuan LeeDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.

Funding

National Science Foundation NSF 2406029STU Scientific Research Initiation Grant NTF25001T
6 · The paper itself

Abstract

purposeMyocardial reactive interstitial fibrosis (RIF) is a common feature in heart failure (HF) and is associated with changes in the structure and function of the heart. The impact of interstitial space enlargement and accumulation of interstitial collagen on oxygen transport from capillaries to cardiomyocytes during RIF is not fully understood.

methodsTo address this issue, we developed a histology-image-based computer modeling approach to estimate the spatial profile of pO

resultsThe analysis shows that both interstitial space enlargement and RIF significantly limit tissue oxygenation, as evidenced by a ~ 47% lower pO

conclusionThese findings provide quantitative evidence that interstitial space enlargement and RIF substantially affect O

Indexed as

Computational modeling and simulationHeart failureHistological imagesMyocardial interstitial fibrosisOxygen transport

Identifiers

PMID42268487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.