Evidence map›Paper›PMID 42268415›Full record

ArticleEuropean journal of clinical pharmacology2026

Efficacy of NEPA for prevention of chemotherapy induced nausea and vomiting in head and neck cancer patients receiving cisplatin-based chemotherapy.

Tzer-Zen Hwang, Chih-Chun Wang, Chuan-Chien Yang, Ching-Feng Lien, Chien-Chung Wang, Yu-Chen Shih, Shyh-An Yeh, Tai-Heng Yeh, Meng-Che Hsieh

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Article in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Tzer-Zen HwangDepartment of Otolaryngology, E-Da Hospital, Kaohsiung, 82445, Taiwan.
Chih-Chun WangDepartment of Otolaryngology, E-Da Hospital, Kaohsiung, 82445, Taiwan.
Chuan-Chien YangDepartment of Otolaryngology, E-Da Hospital, Kaohsiung, 82445, Taiwan.
Ching-Feng LienDepartment of Otolaryngology, E-Da Hospital, Kaohsiung, 82445, Taiwan.
Chien-Chung WangDepartment of Otolaryngology, E-Da Hospital, Kaohsiung, 82445, Taiwan.
Yu-Chen ShihCollege of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan.
Shyh-An YehCollege of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan.
Tai-Heng YehDepartment of Otolaryngology, E-Da Hospital, Kaohsiung, 82445, Taiwan.
Meng-Che HsiehCollege of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan. philips115@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) in combination with a neurokinin-1 receptor antagonist (NK-1RA) are effective for the prevention of chemotherapy induced nausea and vomiting.

objectivesWe investigated the efficacy between oral netupitant and palonosetron (NEPA) and intravenous fosaprepitant and palonosetron (FOPA) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients treated with cisplatin-based chemotherapy.

methodsR/M HNSCC patients who were treated with cisplatin-based chemotherapy as first-line treatment were enrolled in our study. All patients were stratified according to anti-emetic agents, classifying into NEPA group and FOPA group. Anti-emetic efficacy, patients self-report scores and hospitalization days were compared between NEPA and FOPA.

resultsA total of 425 R/M HNSCC patients were recruited into our study, with 211 patients in NEPA and 214 patients in FOPA. Anti-emetic efficacy were all significantly better with NEPA than with FOPA across cycle 1 to 5. The mean nausea score were 2.9 vs. 3.4 (p = 0.004) and the mean vomiting score were 1.4 vs. 2.7 (P = 0.001) in cycle 1 for NEPA group and FOPA group, respectively. The mean satisfaction scores were 8.5 vs. 8.2 ( P = 0.032) in cycle1 for NEPA group and FOPA group, respectively. Furthermore, the mean hospitalization days were shorter in NEPA than those in FOPA across cycle 1 to 5, with mean hospitalization days 6.0 versus 7.0 days in cycle 1, respectively.

conclusionsOral NEPA exhibited a superior anti-emetic efficacy than intravenous FOPA, as well as shorter hospitalization days for R/M HNSCC patients treated with cisplatin-based chemotherapy.

Indexed as

AntiemeticsAntineoplastic AgentsCisplatinHead and Neck NeoplasmsNauseaPalonosetronPyridinesQuinuclidinesVomitingAdultAgedFemaleHumansMaleMiddle AgedMorpholinesAntiemeticsAntineoplastic AgentsCisplatinfosaprepitantMorpholinesNeurokinin-1 Receptor AntagonistsPalonosetronPyridinesQuinuclidinesChemotherapy induced nausea and vomitingCisplatin-based chemotherapyHead and neck cancerNetupitant/palonosetron

Identifiers

PMID42268415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.