Evidence map›Paper›PMID 42267882›Full record

ArticleCancer biomarkers : section A of Disease markers

The clinical assessment of miR-34a and miR-135b panel as promising diagnostic biomarkers predict the risk of colorectal cancer: A case-control study.

Roya Karami, Elaheh Najafi, Anahita Babaei, Erfan Shahdoust, Ali Shaghaghi, Nasrin Amiri-Dashatan, Behrooz Motlagh, Mehdi Koushki, Hadi Khodabandehloo

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Article in Cancer biomarkers : section A of Disease markers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Roya KaramiDepartment of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Elaheh NajafiDepartment of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Anahita BabaeiDepartment of Medical Laboratory, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.
Erfan ShahdoustDepartment of Medical Laboratory, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.
Ali ShaghaghiDepartment of General Surgery, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Nasrin Amiri-DashatanZanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical Sciences, Zanjan, Iran.
Behrooz MotlaghDepartment of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Mehdi KoushkiDepartment of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Hadi KhodabandehlooDepartment of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.ORCID 0000-0001-9288-3338

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundmiRNAs are of interest due to have been involved in cancers such as colorectal cancer (CRC).ObjectiveTo explore the expression levels of miRNA-34a and miRNA-135b and whether they can be potential biomarker for early diagnosis of CRC.MethodsFifteen pairs newly diagnosed colorectal cancer and normal involved in the measurement of tissue and serum levels of miRNAs 34a and 135b and their target genes of SIRT1 and DAPK-1. We assessed the predictive value of these miRNAs utilizing the receiver operating characteristic curve.ResultsThe findings have shown that the miRNA-34a expression was significantly downregulated and miRNA-135b was upregulated in CRC tissues in comparison to their expression in adjacent normal tissue. This was additionally observed in the serum of the same CRC cases when compared to individuals without CRC. Furthermore, we found a significant increase in the level of SIRT-1 and a significant reduction in the expression level of DAPK-1 in CRC tissues compared to the adjacent normal tissue. The value of AUC was considerably high for the timely detection of CRC.ConclusionsWe found these miRNAs acting as potential non-invasive biomarkers for the early detection of CRC and in assessing the CRC risk within the general population.

Indexed as

Biomarkers, TumorColorectal NeoplasmsMicroRNAsAgedCase-Control StudiesDeath-Associated Protein KinasesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedROC CurveSirtuin 1Biomarkers, TumorDAPK1 protein, humanDeath-Associated Protein KinasesMicroRNAsMIRN135 microRNA, humanMIRN34 microRNA, humanSIRT1 protein, humanSirtuin 1biomarkercolorectal cancermicroRNA-135bmicroRNA-34atarget gene

Identifiers

PMID42267882
PMCPMC13254432

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