Evidence map›Paper›PMID 42267842›Full record

ArticleMicrobiology spectrum2026

The inner membrane complex protein, IMC55, is dispensable for intraerythrocytic development of

Grace W Vick, Manuel A Fierro, Annabella Castiglione, Lenna Park, Carrie Brooks, Vasant Muralidharan

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Grace W VickCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-4796-1637
Manuel A FierroCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Annabella CastiglioneCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Lenna ParkDepartment of Cellular Biology, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, USA.
Carrie BrooksCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Vasant MuralidharanCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-6367-6284

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Exocytosis of Plasmodium egress and invasion organellesR56AI173133 · NIAID · UNIVERSITY OF GEORGIA · PI MURALIDHARAN, VASANT · 2023 to 2023
$540k
Regulation of calcium signaling in the human malaria parasiteR21AI133322 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N, MURALIDHARAN, VASANT · 2018 to 2019
$414k
National Institute of Allergy and Infectious Diseases R21AI133322, R56AI173133National Institute of Allergy and Infectious Diseases T32AI060546NIAID NIH HHS R21 AI133322NIAID NIH HHS R56 AI173133NIAID NIH HHS T32 AI060546
6 · The paper itself

Abstract

IMPORTANCE: The inner membrane complex or IMC is a set of flattened cisternal membrane compartments originating from the ancestral Alveolata lineage, where it is shared among ciliates, dinoflagellates, as well as Apicomplexans like Plasmodium and Toxoplasma. We identified a transmembrane protein known as IMC55, and using multiple conditional systems, show that it is not required for

Indexed as

ErythrocytesMembrane ProteinsPlasmodium falciparumProtozoan ProteinsAnimalsHumansMalaria, FalciparumMerozoitesMembrane ProteinsProtozoan Proteinsinner membrane complexmalariaPlasmodium falciparum

Identifiers

PMID42267842
PMCPMC13339899

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.