Evidence map›Paper›PMID 42267837›Full record

ArticlemSphere2026

Genome-scale dissection of phase-variable gene function in

Shouji Yamamoto, Ken-Ichi Lee, Akiko Kubomura, Sunao Iyoda, Yukihiro Akeda, Takaaki Shimohata, Chihiro Aikawa, Masashi Okamura, Fuhito Hojo, Takako Osaki and 1 more

Abstract read
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shouji YamamotoDepartment of Bacteriology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku City, Tokyo, Japan.ORCID 0000-0002-5264-7071
Ken-Ichi LeeDepartment of Bacteriology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku City, Tokyo, Japan.ORCID 0000-0002-4765-0989
Akiko KubomuraDepartment of Bacteriology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku City, Tokyo, Japan.ORCID 0000-0002-3220-3334
Sunao IyodaDepartment of Bacteriology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku City, Tokyo, Japan.
Yukihiro AkedaDepartment of Bacteriology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku City, Tokyo, Japan.
Takaaki ShimohataFaculty of Marine Biosciences, Fukui Prefectural University, Fukui, Japan.
Chihiro AikawaDivision of Veterinary Science, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Masashi OkamuraDivision of Veterinary Science, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Fuhito HojoGraduate School of Medicine, Institute of Laboratory Animals, Kyorin University, Mitaka, Tokyo, Japan.
Takako OsakiDepartment of Infectious Diseases, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Jiro MitobeDepartment of Infectious Diseases, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phase variation (PV) allows bacterial pathogens to rapidly modify surface structures through reversible mutations-often driven by simple sequence repeats (SSRs)-thereby facilitating immune evasion and environmental adaptation. In IMPORTANCE: Phase variation allows bacteria to rapidly generate phenotypic diversity, but its randomness has long limited efforts to define how specific gene combinations influence adaptation. In

Indexed as

Campylobacter jejuniGenome, BacterialPhase VariationAnimalsCampylobacter InfectionsChickensHumansMiceCampylobacter jejunigenome editinghost adaptationphase variation

Identifiers

PMID42267837
PMCPMC13317227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.