Evidence map›Paper›PMID 42267834›Full record

ReviewClinical microbiology reviews2026

Gut microbiota-derived short-chain fatty acids (SCFAs): immunomodulatory effects and therapeutic potential in infections.

Junxiu Yu, Wenweiran Li, Yajie Xu, Jianguo Tang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical microbiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junxiu YuDepartment of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID 0009-0002-2501-0603
Wenweiran LiDepartment of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID 0009-0004-3914-421X
Yajie XuDepartment of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID 0009-0007-4742-4942
Jianguo TangDepartment of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-1263-7327

Funding

the Minhang District Major Medical Discipline Construction Project 2024MWDXK01the National Natural Science Foundation of China 32301086the Science and Technology Innovation Plan of the Shanghai Science and Technology Commission 22ZR1448800
6 · The paper itself

Abstract

SUMMARYThe human gut microbiotas constitute a complex microecosystem essential for host homeostasis. Among its metabolites, short-chain fatty acids (SCFAs) act as key signaling molecules linking microbial activity to host immunity and barrier function. Based on existing literature, we conducted a comprehensive analysis of the interaction between SCFAs and 11 key gut pathogens. These pathogens include bacteria (i.e.,

Indexed as

Fatty Acids, VolatileGastrointestinal MicrobiomeImmunologic FactorsAnimalsBacteriaHumansImmunomodulationFatty Acids, VolatileImmunologic Factorsadjuvant therapyanti-infectivegut microbiotaintestinal barriermicrobiota-host interactionshort-chain fatty acids

Identifiers

PMID42267834
PMCPMC13560681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.