ArticleJournal of virology2026
Promotion of hepatitis B virus infection by extracellular apolipoprotein E.
Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Chronic hepatitis B virus (HBV) infection remains a major burden to global health, affecting more than 250 million people worldwide. HBV and host interactions determine the HBV chronicity. Our previous studies have found that human apolipoprotein E (apoE) is incorporated in infectious HBV virions and plays important roles in HBV infection and morphogenesis. ApoE mediates HBV cell attachment through its interaction with cell surface receptors such as the low-density lipoprotein receptor (LDLR) family members and heparan sulfate proteoglycans (HSPGs). More importantly, both HBV-associated apoE and its expression in hepatocytes are critical for efficient HBV infection. However, the importance of extracellular apoE in HBV infection has not been examined. In the present study, we have determined the role of extracellular apoE in HBV infection IMPORTANCE: Human apolipoprotein E (apoE) is implicated in the infection of different viruses as an entry-promoting factor. Our previous studies have demonstrated that apoE is enriched in the envelopes of hepatitis B virus (HBV) and hepatitis C virus (HCV)and promotes their infection and morphogenesis
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