ArticleZoological research2026
First identification of an amphibian-derived peptide with anti-vascular aging activity.
Article in Zoological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Formulation Attributes and Preclinical Wound Healing Outcomes of Natural Product Based Nanoemulsions: A Systematic Review.International journal of nanomedicine · 2026Pooled it
- Fufang Huangbo Formula mitigates myeloproliferative neoplasms by activating p53/p21 signaling axis and inhibiting STAT3 and NF-κB signaling pathways.Pharmaceutical science advances · 2026Article
- miR-125a-5p inhibits NF-κB by negatively regulating TRAF2 to alleviate inflammatory injury in ischemic stroke rats.IBRO neuroscience reports · 2026Article
- Gut microbiota-mediated uric acid metabolism: Novel insights for developing urate-lowering and anti-gout medications.Pharmaceutical science advances · 2026Review
- A Novel Cationic Antimicrobial Peptide ScymidgutinProbiotics and antimicrobial proteins · 2026Article
- Wuguchong Bioactive Peptides Promote Wound Healing via Hedgehog Pathway‑Mediated Fibroblast Modulation.Chemistry & biodiversity · 2026Article
- Tetrasulfide-bridged virus-like particles enable host-sparing cascade membrane-metabolic disruption for drug-resistant bacterial keratitis.Journal of nanobiotechnology · 2026Article
- Food-derived peptide RDP3 mitigates pyroptosis to enhance oral mucosal repair via the IL-2Rβ/PI3K axis.NPJ Regenerative medicine · 2026Article
- Zinc ion-releasing immunomodulatory hydrogels for enhanced wound healing.Regenerative biomaterials · 2026Article
- Engineered Marine Polysaccharide Carriers for Targeted Delivery in Diabetes Management.International journal of nanomedicine · 2026Review
- Multifunctional pH-responsive HA-c-FZ1 hydrogel presents a promising therapeutic strategy for diabetic skin wounds.Burns & trauma · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular aging is a principal driver of cardiovascular morbidity and mortality, and effective prevention of age-related vascular pathologies depends on interventions that target fundamental molecular and cellular aging pathways. The present study investigated the anti-vascular aging activity of AL-VI10, a novel bioactive peptide derived from amphibian skin, together with the underlying mechanism. Notably, AL-VI10 exhibited excellent biosafety, with no detectable cytotoxic or hemolytic activity, and showed potent free radical scavenging capacity, enhanced antioxidant enzyme activity, and reduced reactive oxygen species (ROS) accumulation. In a D-galactose-induced mouse model of aging, AL-VI10 significantly attenuated vascular aging-associated phenotypes, including increased medial thickness, elevated expression of inflammatory cytokines, and up-regulation of matrix metalloproteinase levels, while simultaneously promoting autophagy. In hydrogen peroxide (H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.