Trial reportActa orthopaedica2026
6-week cryo-compression therapy and opioid use after unicompartmental knee arthroplasty with comparable pain scores: a secondary analysis of a randomized controlled trial.
Trial report in Acta orthopaedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05572359 (Effect of Cryo- and Compression Therapy After Total Knee and Unicompartmental Arthroplasty, A Randomised Controlled Trial), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Effect of Cryo- and Compression Therapy After Total Knee and Unicompartmental Arthroplasty, A Randomised Controlled Trial
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCryo-compression benefits after knee arthroplasty appear short-lived. Evidence in unicompartmental knee arthroplasty (UKA) is particularly scarce. We aimed to assess 6-week cryo-compression on pain (including oxycodone consumption), function, and quality of life (QoL) at 6 weeks following UKA compared with standard care.
methodsIn this single-center, single-blind randomized controlled trial (NCT05572359), adults scheduled for UKA were randomly assigned (1:1) to the regular or cryo-compression group. The cryo-compression group was instructed to use the cold compression brace 5 times daily for 6 weeks. Primary outcome (Numeric Rating Scale [NRS] pain at rest) and secondary outcomes (NRS pain during loading, Knee Injury and Osteoarthritis Outcome Score-subscales, Oxford Knee Score, Work, Osteoarthritis and joint-Replacement Questionnaire [WORQ], physical tests, EuroQol 5-Dimensions 5-Level [EQ5D-5L]) were measured preoperatively and at 6 weeks. Oxycodone consumption was recorded daily.
resultsAt 6 weeks, there was no between-group difference in pain at rest (mean difference 0.1 points, CI -0.6 to 0.9). The cryo-compression group consumed 46% less oxycodone over the 6 weeks (CI 9-68), with an absolute median difference of 3.5 5-mg tablets in total. WORQ and EQ5D-5L index-scores improved more in the cryo-compression group (8.7 points, CI 0.7-16.6, and 0.10 points, CI 0.03-0.2, respectively), but neither reached the minimal clinically important difference (13 and 0.11).
conclusion6-week cryo-compression following UKA demonstrated no differences in pain at rest or functional and QoL-related outcomes. Oxycodone consumption was lower in the cryo-compression group, although absolute differences were small.
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