Evidence map›Paper›PMID 42267464›Full record

ArticleThe European journal of neuroscience2026

Effortful Control and Cortical Brain Structure in 5-Year-Old Children: Findings From the FinnBrain Birth Cohort Study.

Meri Frantti, Jetro J Tuulari, Saara Nolvi, Elisabeth Nordenswan, Anni Copeland, Venla Kumpulainen, Eero Silver, Harri Merisaari, Ekaterina Saukko, Eeva-Leena Kataja and 4 more

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meri FranttiFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0009-0005-4060-1825
Jetro J TuulariFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Saara NolviFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Elisabeth NordenswanFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Anni CopelandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Venla KumpulainenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Eero SilverFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Harri MerisaariFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-8515-5399
Ekaterina SaukkoDepartment of Radiology, Turku University Hospital and University of Turku, Turku, Finland.
Eeva-Leena KatajaFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Riikka KorjaFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Linnea KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Hasse KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Elmo P PulliFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.

Funding

Academy of Finland 346790Alfred Kordelinin SäätiöEmil Aaltosen SäätiöEmil Aaltosen Säätiö, Juho Vainion SäätiöFinnish Brain FoundationFinnish Cultural FoundationFinnish State Grants for Clinical Research (ERVA/VTR)Frilasarettet Eschnerska StiftelsenJuho Vainion SäätiöOrionin TutkimussäätiöPäivikki and Sakari Sohlberg FoundationResearch Council of Finland 26080983Research Council of Finland 346121Research Council of Finland 352648Signe ja Ane Gyllenbergin SäätiöSigrid Juséliuksen SäätiöThe Centre for ExellenceTurun YliopistosäätiöVarsinais-Suomen Sairaanhoitopiiri
6 · The paper itself

Abstract

The aim of this study was to explore the associations between an aspect of self-regulation (SR), effortful control (EC) and cortical brain structure in 5-year-old children. Efficient EC is a predictor of many attributes and important outcomes in life, such as social-emotional functioning, finance, psychiatric and somatic health. The early brain correlates of EC are not widely studied, and a better understanding of them would aid in understanding how self-regulatory capacities emerge over development. Participants (N = 155) were a part of the FinnBrain Birth Cohort Study in Finland. T1-weighted brain magnetic resonance images were processed using FreeSurfer. The data were statistically analysed with a vertex-wise general linear model. At the age of 5 years, EC was assessed via parental report using The Children's Behaviour Questionnaire. We found positive associations between EC and cortical volume in the left supramarginal region and in the right inferior temporal region. We also found positive associations between EC and surface area on the left hemisphere in the superior parietal region. We extended the previous literature by shedding light on early structural brain correlates of EC in a large sample of typically developing 5-year-olds. The main results differed significantly from previous findings in older children. The results were only present with questionnaire- and not task-based evaluation of EC. Both questionnaire and task-based evaluations are required to consider different aspects of EC and SR. In addition, longitudinal studies are needed to better understand the neural underpinnings of SR throughout development.

Indexed as

Cerebral CortexChild DevelopmentSelf-ControlBirth CohortChild, PreschoolCohort StudiesFemaleFinlandHumansMagnetic Resonance ImagingMaleeffortful controlMRIneuroimagingself‐regulationtemperament

Identifiers

PMID42267464
PMCPMC13250741

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.