Evidence map›Paper›PMID 42267441›Full record

ArticlePsychological medicine2026

Computerized assessments of emotional expression and emotional reactivity predict negative symptoms in individuals at clinical high-risk for psychosis.

Claire Emilie Bertrand, Victor J Pokorny, James M Gold, James A Waltz, Jason Schiffman, Lauren M Ellman, Gregory P Strauss, Elaine F Walker, Scott W Woods, Albert R Powers and 4 more

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Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Claire Emilie BertrandDepartment of Psychology, Northwestern University, Evanston, IL, USA.ORCID 0009-0003-8019-8626
Victor J PokornyDepartment of Psychology, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-1003-0196
James M GoldMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0109-9554
James A WaltzMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9236-3719
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-1363-4497
Lauren M EllmanDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA.ORCID 0000-0002-7218-5169
Elaine F WalkerDepartment of Psychology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-9798-8101
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0002-3103-5228
Albert R PowersDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0003-3057-5043
Joshua KenneyDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0002-7780-5988
Philip R CorlettDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0002-5368-1992
Steven M SilversteinDepartments of Psychiatry, Neuroscience, and Ophthalmology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-0699-0960
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, IL, USA.

Funding

National Institute of Mental Health and Neurosciences R01MH120088
6 · The paper itself

Abstract

backgroundNegative symptoms are a core feature of psychosis and a strong predictor of functional outcome, yet they remain difficult to assess due to conceptual and methodological challenges. Although abnormalities in emotional expressivity and emotional reactivity are documented in individuals at clinical high-risk (CHR) for psychosis, these domains are typically examined independently, and their relationship remains unclear.

methodsFacial expressions were quantified using automated facial analysis (FaceReader) during clinical interviews in 101 CHR individuals and 41 healthy controls (HCs). Emotional reactivity was assessed using the International Affective Picture System (IAPS). Principal component analyses were conducted on facial expression and emotional reactivity variables within the CHR group. Associations with negative symptom domains, positive symptoms, and social functioning were examined using correlational and two-step regression analyses.

resultsCHR participants showed greater disgust expression than HCs (g = 0.40, uncorrected

conclusionsAutomated facial expression captured variance in some negative symptom domains that was largely independent of emotional reactivity. These findings support the use of multimodal, objective assessments to improve characterization of negative symptoms in psychosis risk.

Indexed as

EmotionsFacial ExpressionPsychotic DisordersAdolescentAdultFemaleHumansMaleYoung AdultanhedoniaAutomated facial expressionclinical high-riskEmotional reactivitynegative symptomsPsychosis

Identifiers

PMID42267441
PMCPMC13280694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.