Evidence map›Paper›PMID 42267423›Full record

ArticlePhytotherapy research : PTR2026

In Vivo Evidence of Human Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 Mediated Disposition of Glycyrrhizin and Its Drug-Drug Interactions in Humanized Mice.

Jiajia Dong, Jiajing Zhong, Xiangnan Wang, Doudou Geng, Chunqin Mao, Zhipeng Chen, Tulin Lu

Abstract read
In one paragraph

Article in Phytotherapy research : PTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiajia DongDepartment of Pharmacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Jiajing ZhongDepartment of Pharmacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Xiangnan WangKey Research Laboratory of Chinese Medicine Processing of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing, China.
Doudou GengDepartment of Pharmacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Chunqin MaoDepartment of Pharmacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Zhipeng ChenDepartment of Pharmacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Tulin LuDepartment of Pharmacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Funding

Jiangsu Provincial Health Commission Z2025066National Natural Science Foundation of China 82104700
6 · The paper itself

Abstract

Organic anion-transporting polypeptide (OATP) transporters have a significant influence on the disposition of drugs, significantly influencing their efficacy and toxicity. Humans express two transporters (OATP1B1 and OATP1B3), while murine possess only a single ortholog (Oatp1b2). To elucidate the impact of OATP1B1 and 1B3 on the pharmacokinetics of the hepatoprotective agent glycyrrhizin and its potential drug-drug interactions, we conducted a study utilizing wild-type, murine Oatp1b2 knockout, and newly generated humanized OATP1B1 and OATP1B3 transgenic mice (Slco1b2

Indexed as

Glycyrrhizic AcidLiver-Specific Organic Anion Transporter 1Solute Carrier Organic Anion Transporter Family Member 1B3AnimalsDrug InteractionsHumansLiverMaleMiceMice, KnockoutMice, TransgenicGlycyrrhizic AcidLiver-Specific Organic Anion Transporter 1SLCO1B1 protein, humanSLCO1B3 protein, humanSolute Carrier Organic Anion Transporter Family Member 1B3drug–drug interactionsglecaprevir/Pibrentasvirglycyrrhizinhepatic uptakehumanized transgenic mice modelOATP1B transporterspharmacokinetics

Identifiers

PMID42267423
PMCPMC13548940

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.