ArticleACS applied materials & interfaces2026
Organization and Dynamics of Focal Adhesions: Light Diffraction Analysis of Cellular Adhesion on Nanopatterned Surfaces.
Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study presents the first application of nanophotonic sensing modality for investigating live-cell adhesion, introducing a novel label-free optical method to monitor specific nanoscale structural changes at the cell-substrate interface. Our method utilizes receptor molecules immobilized in a diffraction pattern with a precise submicron periodicity, which provides superior sensing volume confinement through the spatial lock-in amplification principle. This internal nanoscale ruler enables the investigation of otherwise diffraction-limited phenomena with higher specificity and reduced background noise, ultimately providing more insight into nanoscale adhesion organization dynamics. To complement this approach, resonant waveguide grating (RWG) biosensing and holographic microscopy were used to characterize adhesion behavior and morphological changes of HeLa cells on RGD-functionalized substrates. The nanophotonic readout revealed distinct multistep adhesion dynamics associated with integrin clustering, nanoscale redistribution of adhesion-associated molecular assemblies, and focal adhesion remodeling. Quantitative analysis estimated that approximately 1.22 × 10
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