Evidence map›Paper›PMID 42267375›Full record

ArticleERJ open research2026

Frailty and social, clinical and computed tomography imaging factors in COPD: a multicentre study.

Yusuke Shiraishi, Naoya Tanabe, Tomoki Maetani, Yohei Oshima, Yuji Yoshioka, Ryota Hamada, Masamitsu Enomoto, Michiko Tsuchiya, Ryo Tachikawa, Yuichi Chihara and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yusuke ShiraishiDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0003-4978-5673
Naoya TanabeDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-7481-0212
Tomoki MaetaniDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yohei OshimaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
Yuji YoshiokaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
Ryota HamadaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
Masamitsu EnomotoDepartment of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.
Michiko TsuchiyaDepartment of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.ORCID https://orcid.org/0009-0006-9699-4039
Ryo TachikawaDepartment of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Yuichi ChiharaDepartment of Respiratory Medicine, National Hospital Organization Minami-Kyoto Hospital, Joyo, Japan.
Kunihiko TeradaTerada Clinic, Respiratory Medicine and General Practice, Himeji, Japan.
Satoru TeradaDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Motonari FukuiRespiratory Disease Center, Medical Research Institute, Kitano Hospital, PIIF Tazuke-Kofukai, Osaka, Japan.
Kaori IkedaDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0003-2273-9693
Atsuyasu SatoDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Susumu SatoDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-9626-1090
Toyohiro HiraiDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-7431-9044

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Frailty often coexists in patients with COPD regardless of disease severity and may serve as a treatable trait. We hypothesised that factors associated with frailty may differ by COPD severity. This study aimed to comprehensively explore related factors including symptoms, physical activity, dietary behaviour, serum biomarkers and computed tomography (CT) parameters. Methods: This cross-sectional analysis of a multicentre prospective cohort study included patients with COPD aged ≥50 years with a smoking history ≥10 pack-years. Frailty was assessed using the Kihon checklist. Data were collected using questionnaires on symptoms, physical activity and dietary behaviour, as well as blood tests and CT parameters. Associations between frailty and clinical variables were assessed using multivariable linear and logistic regressions in all patients and within the COPD severity subgroups. Results: Among 225 patients, 45 (20%) were diagnosed with frailty. These patients were older, more likely to have cardiovascular disease (CVD) and had a higher neutrophil-to-lymphocyte ratio. Stratified by COPD severity, age, forced expiratory volume in 1 s (FEV Conclusion: Social factors, comorbidities and WA% were associated with frailty in patients with COPD. Social factors were more relevant in patients with mild COPD.

Identifiers

PMID42267375
PMCPMC13244204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.