ArticleERJ open research2026
Small airways obstruction predicts cardiovascular disease incidence: a longitudinal study of UK Biobank.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: Isolated small airways obstruction (SAO) is common, a precursor of COPD and associated with increased cardiovascular disease (CVD) mortality. Whether isolated SAO predicts CVD incidence is unknown. Methods: Using longitudinal data on 139 568 UK Biobank participants (median age 58 years), we calculated CVD incidence in those with, Results: At baseline, 10 480 participants (7.5%) had isolated SAO. During follow-up (median 9.2 years), CVD was diagnosed in 30 763 (22%) participants, more commonly among those with isolated SAO at baseline (risk ratio 1.05 (95% CI 1.01-1.09)). This association was not significant in males (risk ratio 1.03 (95% CI 0.98-1.08)) nor in never-smokers (risk ratio 1.02 (95% CI 0.97-1.09)). The risk of CVD was increased when isolated SAO was defined using FEF Conclusions: Adults with isolated SAO have a modest increased risk of developing CVD. However, this association is potentially driven by smoking. Further research should explore underlying mechanisms for this increased risk and how best this can be mitigated.
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