ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026
MHR and CRP/Albumin Ratio Correlate with Wagner Grade in Diabetic Foot Ulcers: A Chinese Retrospective Study with Pathogen Analysis.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Assessing the severity of diabetic foot ulcers (DFU) is critical for prognosis and treatment. While the Wagner classification is widely used, it lacks systemic inflammatory and nutritional assessment. Composite markers like the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and C-reactive protein-to-albumin ratio (CAR) may fill this gap. Furthermore, regional data on pathogen distribution in China are essential for guiding antibiotic therapy. Aim: To investigate the correlation of MHR and CAR with Wagner grades in Chinese DFU patients, identify independent predictors for severity, and analyze pathogen distribution and drug resistance patterns across different grades. Patients and Methods: A retrospective analysis was conducted on 136 DFU patients hospitalized from January 2022 to May 2024. Patients were categorized into three groups based on Wagner grades: Grade 1-2 (n=17), Grade 3 (n=42), and Grade 4-5 (n=77). Clinical data, MHR, and CAR were analyzed. Spearman correlation and ordinal logistic regression determined associations with severity. Receiver operating characteristic (ROC) curves evaluated the predictive value of MHR and CAR for severe infection (Wagner 4-5). Pathogen profiles were analyzed per group. Results: MHR (r=0.451, Conclusion: MHR and CAR are valuable biological markers for assessing DFU severity in the Chinese population. Albumin and HDL-C serve as independent protective factors. The study reveals a grade-dependent shift in pathogen spectra toward Gram-negative bacteria and mixed infections, providing region-specific evidence for optimizing empirical antibiotic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.