ArticleJournal of advanced periodontology & implant dentistry2026
Association between HLA molecules and stage III/IV grade C periodontitis in a Moroccan population: A case-control study.
Article in Journal of advanced periodontology & implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Literature data support the important role played by HLA molecules in predisposing to periodontitis. The present study evaluated possible associations between HLA class I and II phenotypes and stage III/IV grade C periodontitis in a Moroccan population. Methods: The sample comprised 26 patients aged 15‒30 years, diagnosed with stage III/IV grade C periodontitis (case group) and 202 patients ethnically similar to the case group (control group). The patients underwent phenotyping for HLA class I molecules using the BIOTEST microlymphocytic plate technique and genotyping for HLA DR molecules. Bivariate analysis was performed using the chi-squared test at a significance level of Results: The results showed a variable distribution of A alleles, without any specificity, predominantly in periodontitis cases compared with the controls. B21 allele was found with a lower phenotypic frequency (10.34%) in periodontitis cases compared with controls (31.18%) (χ Conclusion: The present case‒control study reported a negative association between B21 and DR6 alleles and stage III/IV grade C Moroccan periodontitis cases compared with the controls with verified healthy periodontal status. This may help explain the particular profile of stage III/IV grade C periodontitis in Moroccan patients.
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