ArticleFrontiers in psychiatry2026
Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cadmium(Cd) exposure is associated with anxiety, but mechanism-informed multi-target interventions are limited. Methods: We profiled plasma proteomes by LC-MS/MS in a propensity-score-matched Cd-exposed cohort (25 anxious vs 25 non-anxious). Anxiety-associated proteins were used as seeds for reverse screening in TCMIP v2.0, followed by network integration, molecular docking, 100ns molecular dynamics simulations, and rat validation of a ginseng-mulberry leaf (medicine-food homologous) decoction. Results: Proteomics identified 120 differentially expressed proteins associated with anxiety. Network screening prioritized ginseng and mulberry leaf; quercetin and kaempferol showed strong and stable binding to AKT1, PTGS2, and HSP90AA1. In Cd-exposed rats, the decoction increased open-field center exploration without altering locomotion, attenuated prefrontal perivascular enlargement and glial dysmorphology, and restored AKT1/PTGS2 immunofluorescence. Conclusions: A clinical proteomics-initiated discovery pipeline suggests a poly-pharmacological intervention for Cd-induced neurotoxicity. The ginseng-mulberry leaf pair counteracts Cd-associated neurobehavioral and prefrontal changes and warrants dose-response and target-perturbation studies.
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