Evidence map›Paper›PMID 42267144›Full record

ArticleCurrent opinion in physiology2025

Role of extracellular vesicle-mediated neurodegeneration in substance use disorders.

Mohit Kumar, Arnab Saha, Agasou Alfonso Rameau, Susmita Sil, Shilpa Buch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohit KumarDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
Arnab SahaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
Agasou Alfonso RameauDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
Susmita SilDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
Shilpa BuchDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.

Funding

Molecular mechanisms underlying HIV & Cocaine-mediated microglial activation: Targeting NLRP3 inflammasomeR01DA050545 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., GUO, MINGLEI · 2019 to 2023
$2.8M
Combinatorial effects of HIV, cART, & morphine on neuroinflammation: implications for HANDR01DA044586 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., GUO, MINGLEI · 2017 to 2021
$1.9M
Mechanisms underlying dysregulated neuroimmune signaling and neuronal dysfunction in HIV (+) individuals with cART and cocaineR01DA047156 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., GUO, MINGLEI · 2018 to 2022
$1.8M
HIV Tat and Opiate-mediated aberrations in glial-neuronal crosstalk: Implications for the role of extracellular RNA in HANDR01DA060755 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Shilpa J Buch, Susmita Sil · 2024 to 2026
$1.5M
Astrocytic HIF-1a as a therapeutic target for Alzheimer's-like comorbidity of HANDR21AG069541 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SIL, SUSMITA · 2020 to 2020
$421k
NIA NIH HHS R21 AG069541NIDA NIH HHS R01 DA044586NIDA NIH HHS R01 DA047156NIDA NIH HHS R01 DA050545NIDA NIH HHS R01 DA060755
6 · The paper itself

Abstract

Substance use disorders (SUDs) remain a complicated and widespread public health problem, characterized by obsessive drug and alcohol use, despite adverse consequences. Emerging research suggests that the extracellular vesicles (EVs) play a critical role in mediating drug addiction and several neurodegenerative processes associated with SUDs. EVs, which include exosomes, microvesicles, and apoptotic bodies, are lipid-bilayered vesicles that facilitate intracellular communication throughout the host by shuttling bioactive molecules, such as proteins, lipids, DNA fragments, and RNA, including both coding and noncoding RNAs across recipient cells. The current review is a comprehensive analysis highlighting the potential role of EVs in the onset and progression of SUD, specifically in the context of cocaine, cannabis, methamphetamine, opiates, alcohol, and tobacco. The goal is to offer valuable insights into the underlying mechanism(s) involving EVs in the pathogenesis of SUD, ultimately paving the way for new therapeutic avenues.

Identifiers

PMID42267144
PMCPMC13246149

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.