Evidence map›Paper›PMID 42267064›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2026

Correlation Between Renal Biomarkers, Glomerular Filtration Rate, and Meropenem Clearance in Pediatric Septic Shock.

Brandon Vo, Julie Huynh, Robert H Mak, Jeremiah D Momper, Sean N Avedissian, Edmund V Capparelli, Helen Harvey, Erin Bradley, Nanda Ramchandar, Su Jin Kim and 3 more

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Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Brandon VoDepartment of Biochemistry (BV), University of California Riverside, Riverside, CA.
Julie HuynhSchool of Pharmacy and Pharmaceutical Sciences (JH, JL, JM, EC) and School of Medicine (RM, EC, JB), University of California San Diego, La Jolla, CA.
Robert H MakSchool of Pharmacy and Pharmaceutical Sciences (JH, JL, JM, EC) and School of Medicine (RM, EC, JB), University of California San Diego, La Jolla, CA.
Jeremiah D MomperSchool of Pharmacy and Pharmaceutical Sciences (JH, JL, JM, EC) and School of Medicine (RM, EC, JB), University of California San Diego, La Jolla, CA.
Sean N AvedissianDepartment of Pharmacy Practice and Science (SA), University of Nebraska Medical Center, NE.
Edmund V CapparelliSchool of Pharmacy and Pharmaceutical Sciences (JH, JL, JM, EC) and School of Medicine (RM, EC, JB), University of California San Diego, La Jolla, CA.
Helen HarveyDepartment of Infectious Disease (JB) and Critical Care (EB, HH, NR), Rady Children's Hospital, San Diego, CA.
Erin BradleyDepartment of Infectious Disease (JB) and Critical Care (EB, HH, NR), Rady Children's Hospital, San Diego, CA.
Nanda RamchandarDepartment of Infectious Disease (JB) and Critical Care (EB, HH, NR), Rady Children's Hospital, San Diego, CA.
Su Jin KimDepartment of Pediatrics (SJK), Inha University College of Medicine and Inha University Hospital, Incheon, Republic of Korea.
Eun Mi YangDepartment of Pediatrics (EMY), Chonnam National University College of Medicine and Hospital, Gwangju, Republic of Korea.
John S BradleySchool of Pharmacy and Pharmaceutical Sciences (JH, JL, JM, EC) and School of Medicine (RM, EC, JB), University of California San Diego, La Jolla, CA.
Jennifer LeSchool of Pharmacy and Pharmaceutical Sciences (JH, JL, JM, EC) and School of Medicine (RM, EC, JB), University of California San Diego, La Jolla, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe primary objectives were to identify the correlation between various estimated glomerular filtration rate (eGFR) methods and observed meropenem clearance (CL

methodsWe prospectively assessed children aged 4 weeks to 21 years who received meropenem 20mg/kg IV every 8 hours from 2019 to 2023. Cases with sepsis were compared with controls without sepsis. Plasma meropenem concentrations and renal function biomarkers (serum creatinine [SCr], cystatin C [SCys]) were measured. GFR was estimated using: eGFR-MS (modified Schwartz for <18 years old and CKD-EPI for ≥ 18 years old), 3 equations by Pierce using SCr (eGFR-Cr) or SCys (eGFR-Cys) or their average (eGFR-Avg), and eGFR-Pot (Pottel).

resultsAnalysis included 27 subjects (n = 19 cases and n = 8 controls) with 309 meropenem serum concentrations. Median age was 11.8 (range 0.6-19.6) years, weight 36.3 (7.2-98.0) kg, CL

conclusionsThe renal function of critically ill children, especially with sepsis, was extremely diverse and variable by day. Current eGFR methods had weak correlation to CL

Indexed as

acute kidney injuryaugmented renal clearancemeropenempediatric intensive care unitpediatricsrenal biomarkersrenal function

Identifiers

PMID42267064
PMCPMC13245427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.