ArticleAnnals of thoracic surgery short reports2026
Multicenter Randomized Trial to Prevent Pulmonary Vein Stump Thrombus After Left-Sided Anatomical Lung Resection.
Article in Annals of thoracic surgery short reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Pulmonary vein stump thrombosis (PVST) is frequently detected on follow-up computed tomography in patients who have undergone left-sided anatomical pulmonary resection. In particular, a floating thrombus in the pulmonary vein stump has been identified as a potential cause of several postoperative systemic embolic complications, including cerebral infarction, highlighting the unmet need to improve postoperative outcomes in general thoracic surgery. Methods: This randomized trial aims to confirm the efficacy of postoperative heparin administration in preventing PVST and postoperative cerebral infarction, focusing exclusively on left-sided anatomical pulmonary resections. The primary end point is the frequency of PVST on contrast-enhanced computed tomography scans at postoperative day 5 ± 2. The secondary end point is the frequency of systemic thromboembolic events, including cerebral infarction. The study expects to enroll 250 patients from 26 institutions over 2.5 years. Results: The PV STUDY (Postoperative heparin administration to prevent pulmonary vein stump thrombus after left side anatomical pulmonary resection: Multicenter Randomized Phase II trial) has been open since October 2024, and the trial registration is now ongoing. Conclusions: The primary analysis is scheduled for spring 2027.
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