ArticleAnnals of thoracic surgery short reports2026
Are Lung Allografts From Drug Overdose Deaths Safe to Use for Transplantation? A Nationwide Analysis.
Article in Annals of thoracic surgery short reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
Background: The increase in drug overdose deaths (DODs) has resulted in an increased pool of potential organ donors. We assessed the pattern of use of DOD donors and describe outcomes of lung transplant recipients who received allografts from DOD donors. Methods: The United Network for Organ Sharing registry was used to identify all adult (aged ≥18 years) isolated lung transplant recipients between January 2010 and June 2022. Recipient allografts from DOD donors were compared with allografts from donors who died of other causes. Long-term survival was assessed with unadjusted Kaplan-Meier curves, the log-rank test, and risk-adjusted multivariable Cox proportional hazards models. Results: We identified 28,495 adult lung recipients who met inclusion criteria, and 12.1% (n = 3437) received allografts from DOD donors. The yearly volume of DOD recipients nationwide increased from 67 in 2010 to 531 in 2022 (Mann-Kendall trend test, Conclusions: Use of DOD lungs in lung transplantation has increased in the last decade. Long-term recipient outcomes were similar compared with all other donors. These results support the safety of using DOD lungs.
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