ArticleJournal of the colleges of medicine of South Africa2026
Surgical outcomes of Ahmed Glaucoma Valve Implantation surgery: With mitomycin C and without mitomycin C.
Article in Journal of the colleges of medicine of South Africa, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The Ahmed Glaucoma Valve (AGV) is a commonly used glaucoma drainage device (GDD) in the surgical management of glaucoma patients. Adjunctive mitomycin C (MMC) has demonstrated clear benefits in improving the surgical outcomes of trabeculectomy surgery. The effectiveness of MMC in improving the surgical outcomes of GDDs remains uncertain. This study seeks to compare the surgical outcomes of AGV implantation with and without the use of intraoperative MMC in an African cohort. Methods: This retrospective case series analysed 98 eyes in 95 patients who underwent AGV implantation from 01 January 2016 to 31 December 2021 at two units located in Cape Town, South Africa. The postoperative data collected included intraocular pressure (IOP), medication use, and complications. Results: The eyes were categorised into the MMC use ( Conclusion: This study found no difference between the two groups in terms of IOP control, postoperative medication use, and complications. This may be attributed to the low concentration of MMC used in our cohort. Contribution: This study provides insights into the role of MMC use in AGV implantation.
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