ArticleInternational journal of chronic obstructive pulmonary disease2026
Safety and Feasibility of an Asynchronous AI-Integrated Tele-Pulmonary Rehabilitation Application Among Patients with COPD.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Pulmonary rehabilitation (PR) is an effective intervention for patients with chronic obstructive pulmonary disease (COPD), yet its utilization remains very limited. Tele-pulmonary rehabilitation (TPR) may improve access, but the safety and feasibility of asynchronous, app-based programs remain insufficiently studied, especially for patients with severe disease. Patients and methods: This is a retrospective study of patients with COPD who participated in an asynchronous AI-supported TPR program using the ActiveLungs© mobile application between 2022 and 2025. Patients were included if they had spirometry-validated COPD and completed ≥10 training sessions in the application. Safety, feasibility, and adherence with the app trainings were evaluated. Results: A total of 124 patients were included (median age 74 years, 54% female, median FEV1 50%predicted), of whom 55% used long-term oxygen therapy. During the study period, 17,399 trainings and 61,706 exercise sessions were completed. No serious adverse events were reported. Self-reported respiratory worsening occurred in 23% of patients and was associated only with chronic oxygen use (HR 2.68, 95% CI 1.08-6.65, p=0.033). Median (IQR) program use was 129 days (65-433), with trainings performed in 49% (31-64) of the days, and 79% completing more than 24 trainings. All four exercise sessions (2 aerobic and 2 resistance) were completed in 82% of the trainings. Conclusion: An asynchronous, AI-integrated TPR mobile application demonstrated a favorable safety profile and good patient engagement, even in patients with severe COPD. Prospective studies are warranted to evaluate its effectiveness on clinical outcomes.
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