ReviewStem cells international2026
Enamel Matrix Derivative in Dental Pulp Regeneration: Biological Basis, Mechanistic Insights, and Translational Considerations.
Review in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Enamel Matrix Derivative in Dental Pulp Regeneration: Biological Basis, Mechanistic Insights, and Translational Considerations.Stem cells international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enamel matrix derivative (EMD) has attracted increasing attention in regenerative endodontics because of its potential to influence multiple biological processes involved in dental pulp healing. Derived from enamel matrix proteins (EMPs), EMD has been associated with the regulation of stem/progenitor cell migration, odontogenic differentiation, angiogenic activity, and inflammatory responses. This review summarizes current evidence regarding the role of EMD in dental pulp regeneration, with emphasis on its biological characteristics, underlying mechanisms, and integration with biomaterial systems. Available studies suggest that EMD may contribute to a regeneration-permissive microenvironment by modulating cellular behavior and extracellular matrix-related processes, while biomaterial-based delivery strategies have been explored to improve its stability and local bioactivity. However, most existing evidence is derived from in vitro studies or nonpulp regenerative models, and direct evidence supporting functional pulp regeneration remains limited. In addition, EMD, Emdogain, recombinant amelogenin (Am), and Am-derived peptides are closely related but should not be considered interchangeable interventions. Taken together, EMD represents a biologically relevant but not yet fully validated approach in regenerative endodontics, and further studies are required to clarify its mechanisms under clinically relevant conditions and to distinguish true pulp regeneration from partial reparative outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.