Evidence map›Paper›PMID 42266833›Full record

ReviewPsychoradiology2026

Do cognitive reserve proxies capture a common neural signature? A systematic review and meta-analysis of task-based fMRI studies.

Annachiara Crocetta, Jordi Manuello, Donato Liloia, Sergio Duca, Tommaso Costa, Franco Cauda

Abstract readReview
In one paragraph

Review in Psychoradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annachiara CrocettaFunctional Neuroimaging and Complex Neural Systems (FOCUS) Laboratory, Department of Psychology, University of Turin, Via Verdi 10, 10124 Turin, Italy.ORCID https://orcid.org/0009-0001-3408-7322
Jordi ManuelloFunctional Neuroimaging and Complex Neural Systems (FOCUS) Laboratory, Department of Psychology, University of Turin, Via Verdi 10, 10124 Turin, Italy.ORCID https://orcid.org/0000-0002-9928-0924
Donato LiloiaFunctional Neuroimaging and Complex Neural Systems (FOCUS) Laboratory, Department of Psychology, University of Turin, Via Verdi 10, 10124 Turin, Italy.ORCID https://orcid.org/0000-0002-9481-8510
Sergio DucaTranslational Neuroimaging & Brain Connectivity Group, GCS-fMRI, Koelliker Hospital, C.so Galileo Ferraris 247, 10134 Turin, Italy.
Tommaso CostaFunctional Neuroimaging and Complex Neural Systems (FOCUS) Laboratory, Department of Psychology, University of Turin, Via Verdi 10, 10124 Turin, Italy.ORCID https://orcid.org/0000-0002-0822-862X
Franco CaudaFunctional Neuroimaging and Complex Neural Systems (FOCUS) Laboratory, Department of Psychology, University of Turin, Via Verdi 10, 10124 Turin, Italy.ORCID https://orcid.org/0000-0003-1526-8475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive reserve (CR) refers to the capacity of the brain to sustain cognitive performance despite age-related changes or pathophysiological conditions. Task-based functional magnetic resonance imaging (tb-fMRI) has been instrumental in exploring its neural correlates. CR is traditionally assessed through socio-behavioral proxies such as education, intelligence quotient, or composite indices. However, these proxies vary considerably in definition and application, posing challenges regarding their validity and consistency across experiments. This systematic review and meta-analysis examined whether these proxies are associated with consistent brain activation patterns in healthy adults. A literature search identified 12 eligible tb-fMRI experiments (

Indexed as

brain agingcognitive declinecognitive reservefMRIneuroimagingPSI-SDM

Identifiers

PMID42266833
PMCPMC13244274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.