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Conformational Entropy of Intrinsically Disordered Proteins Bars Intruders from Biomolecular Condensates.
Article in PRX life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The exchange dynamics of client molecules in biomolecular condensates.bioRxiv : the preprint server for biology · 2026Article
- Ribosomal allostery as a potential regulator of bacterial dormancy.Nature communications · 2026Article
- Allostery in Biomolecular Condensates.Journal of molecular biology · 2026Review
- Accelerated Ostwald Ripening by Chemical Activity.Journal of the American Chemical Society · 2025Article
- Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions.Communications chemistry · 2025Article
- Computer Simulations Show That Liquid-Liquid Phase Separation Enhances Self-Assembly.ACS nano · 2025Article
- Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions.bioRxiv : the preprint server for biology · 2025Article
- Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region.Nucleic acids research · 2025Article
- Dissecting Rate-Limiting Processes in Biomolecular Condensate Exchange Dynamics.bioRxiv : the preprint server for biology · 2025Article
- Controlled and orthogonal partitioning of large particles into biomolecular condensates.Nature communications · 2025Article
- Fine-tuned interactions between globular and disordered regions of single-stranded DNA binding (SSB) protein are required for dynamic condensation under physiological conditions.Protein science : a publication of the Protein Society · 2025Article
- Structured protein domains enter the spotlight: modulators of biomolecular condensate form and function.Trends in biochemical sciences · 2025Review
- Protein quality control machinery: regulators of condensate architecture and functionality.Trends in biochemical sciences · 2025Review
- Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Controlled and orthogonal partitioning of large particles into biomolecular condensates.bioRxiv : the preprint server for biology · 2024Article
- Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate.bioRxiv : the preprint server for biology · 2024Article
- Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
It was recently discovered that eukaryotic cells are host to a multiplicity of biomolecular condensates. These condensates typically contain protein and/or RNA components with intrinsically disordered regions (IDRs). While IDRs have been proposed and demonstrated to play many roles in condensate biology, we suggest here an additional crucial role of IDRs, which is to exclude unwanted "intruders" from condensates. This exclusion effect arises from the large conformational entropy of IDRs; i.e., there is a high free-energy cost to occupying space that would otherwise be available to the IDRs. By combining polymer theory with sticker-spacer simulations, we show that the relevant insertion free energy increases with the concentration of IDRs in the condensate as well as with intruder size, attaining a linear scaling with surface area for large intruders. We find that at realistic IDR concentrations, particles as small as the size of an average protein (4 nm in diameter) can be 97% excluded from condensates. To overcome this entropic barrier, molecules must interact favorably with condensate components to be recruited as clients. Application of the developed size-exclusion theory to biological condensates suggests that condensate IDRs may play a generic exclusionary role across organisms and types of condensates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.