Evidence map›Paper›PMID 42266710›Full record

ArticleCase reports in ophthalmological medicine2026

CHARGE Syndrome Associated With Persistent Hyperplastic Primary Vitreous: A Case Report.

Li Liu, Liyun Guo, Zailin Xiao, Liwei Zhang, Xuan Ma, Wen Tang, Mei Liu, Shuai Xiong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li LiuYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan, China, ypfph.com.ORCID https://orcid.org/0009-0001-2836-8187
Liyun GuoYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan, China, ypfph.com.ORCID https://orcid.org/0000-0002-7609-7166
Zailin XiaoKunming Aier Eye Hospital, Kunming, Yunnan, China.ORCID https://orcid.org/0009-0006-0909-3874
Liwei ZhangYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan, China, ypfph.com.ORCID https://orcid.org/0000-0002-5174-7134
Xuan MaYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan, China, ypfph.com.ORCID https://orcid.org/0009-0006-0111-9590
Wen TangYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan, China, ypfph.com.ORCID https://orcid.org/0009-0003-0381-5379
Mei LiuYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan, China, ypfph.com.ORCID https://orcid.org/0009-0009-3283-9779
Shuai XiongKunming Aier Eye Hospital, Kunming, Yunnan, China.ORCID https://orcid.org/0009-0009-3285-5728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: CHARGE syndrome is a rare genetic disorder caused primarily by CHD7 mutations, affecting multiple organs, including the eyes, heart, and ears. Ocular abnormalities are common, but bilateral persistent fetal vasculature (PFV) has not been previously reported in CHARGE syndrome. PFV results from the failure of the fetal hyaloid vasculature to regress, typically affecting one eye. Case Presentation: We report a 10-month-old female with bilateral PFV associated with CHARGE syndrome, confirmed by a de novo CHD7 mutation. Systemic evaluation revealed sensorineural hearing loss and congenital cardiac defects. The patient subsequently underwent cataract extraction and intraocular lens implantation in the left eye. Postoperatively, a partial improvement in esotropia was observed. Conclusions: This case represents the first documented instance of bilateral PFV in CHARGE syndrome. It expands the known ocular manifestations of the syndrome and underscores the importance of early genetic diagnosis and multidisciplinary care to optimize patient outcomes.

Indexed as

CHARGE syndromeCHD7 mutationcolobomacongenital cataractpersistent fetal vasculature

Identifiers

PMID42266710
PMCPMC13243766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.