ArticleFrontiers in immunology2026
Mechanistic and functional characterization of NETs/IL-17 as a therapeutic target in EMT and brain metastasis of lung adenocarcinoma.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tumor-associated neutrophils in lung adenocarcinoma: from mechanisms to therapeutic targeting.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lung adenocarcinoma (LUAD) was known to have a propensity for brain metastasis. Neutrophil extracellular traps (NETs) played a role in facilitating tumor metastasis. However, the specific role of IL-17A in triggering the formation of NETs and its impact on NETs-mediated brain metastasis in LUAD was not well understood. Objective: We sought to investigate the IL-17A's role in promoting NET formation, EMT, and brain metastasis in LUAD. Methods: We conducted LASSO and Cox regression analyses to pinpoint the essential genes in NETs that regulate LUAD. We carried out survival assays to validate the significance of the identified key genes. Results: In neutrophils, IL-17A stimulation-induced NET formation may be associated with EP300-mediated increased acetylation of H2BC4. NETs activated IL17 signaling to drive EMT and brain metastasis. NETs enhanced tumor metastasis to brain, which was significantly suppressed by PAD inhibitors or DNase I. Furthermore, acetylated H2BC4, p300, c-Jun, and c-Fos were enriched at the promoter regions of CDH2, VIM, FN1, and ZEB1. Conclusion: Our research showed that IL-17A induced NET formation, and NETs-IL-17A stimulation were associated with increased H2BC4 expression and acetylation during the EMT process and brain metastasis of LUAD. These findings highlight a potential association between the IL-17A/NETs/H2BC4 pathway and the progression of brain metastasis, which may provide possible therapeutic targets for LUAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.