ArticleFrontiers in nutrition2026
Intermittent fasting alleviates ulcerative colitis via lithocholic acid-mediated macrophage reprogramming.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ulcerative colitis (UC) is a relapsing inflammatory disorder, in which nutritional intervention has emerged as a modifiable factor for influencing disease onset and severity. This study aimed to investigate whether intermittent fasting (IF) alleviates UC and identify the underlying mechanisms, focusing on bile acid metabolism-immune system crosstalk. Methods: The study employed a 5:2 IF intervention (5 days Results: 5:2 IF promoted remission of chronic colitis. Mechanistically, IF reshaped gut microbiota composition, enhanced bile acid metabolic flux and elevated LCA levels. LCA directly inhibited pro-inflammatory macrophage polarization via inducing metabolic reprogramming and enhancing mitochondrial oxidative respiration. Analysis of human UC samples revealed that higher LCA levels correlated with milder UC, lower ESR, and reduced calprotectin. Conclusions: IF alleviated chronic experimental colitis by enhancing bile acid metabolism and elevating LCA, which exerted anti-inflammatory effects via regulating macrophage mitochondrial oxidative respiration. This identifies LCA as a key mediating metabolite and provides a mechanistic basis for understanding how IF may affect intestinal inflammation in preclinical models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.