ArticleFrontiers in neurology
Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Zinc homeostasis dysregulation has been implicated in the pathophysiology of ischemic stroke, yet the integrated role of metallothionein (MT), fatty acid desaturase 1 (FADS1), and oxidative DNA damage in elderly ischemic stroke patients remains poorly understood. Objective: To comprehensively evaluate the association between zinc homeostasis dysregulation and acute ischemic stroke in elderly patients through a multidimensional analysis incorporating serum zinc, MT-1, FADS1 activity index, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and inflammatory and oxidative stress markers. Methods: This retrospective case-control study enrolled 400 elderly participants (200 ischemic stroke patients and 200 sex-matched healthy controls) from Qinghe County Central Hospital between July 2024 and July 2025. Serum zinc, metallothionein-1 (MT-1), FADS1 activity index (arachidonic acid/linoleic acid ratio as a surrogate of Δ5-desaturase activity), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and inflammatory and oxidative stress markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], malondialdehyde [MDA], and superoxide dismutase [SOD]) were measured. Spearman correlation, univariate logistic regression, and receiver operating characteristic (ROC) curve analyses were performed. Results: Stroke patients exhibited significantly lower serum zinc (75.78 ± 20.39 vs. 97.94 ± 18.35 μg/dL, Conclusion: Zinc homeostasis dysregulation, characterized by reduced circulating zinc and MT-1 levels alongside elevated FADS1 activity and oxidative DNA damage, is significantly associated with ischemic stroke in elderly patients. These findings suggest that a multidimensional biomarker panel integrating zinc metabolism, lipid signaling, and DNA integrity markers may serve as a useful tool for characterizing the pathophysiological profile of ischemic stroke in elderly patients and warrants further prospective validation for risk stratification.
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