ArticleFrontiers in pediatrics2026
Risk factors analysis for extubation failure following mandibular distraction osteogenesis in infants with Pierre Robin sequence: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mandibular distraction osteogenesis is an important therapeutic approach for infants with Pierre Robin sequence (PRS). There is a lack of data describing risk factors for postoperative extubation failure (EF) in these infants. We aimed to identify risk factors for EF in infants with PRS and to explore the association between EF and clinical outcomes. Methods: A retrospective cohort study was carried out on infants with PRS who received mandibular distraction osteogenesis at our facility from January 2020 to December 2023. Extubation failure was defined as the need for non-invasive ventilation or reintubation within 24 h of extubation. Multivariate logistic regression analysis was performed to explore the risk factors for EF. Univariable statistical analysis was performed to determine associations between EF and clinical outcomes. Results: Of 135 included infants, 27 (20.0%) experienced EF. In the logistic regression analysis, postoperative pneumonia was independently associated with EF ( Conclusions: Postoperative pneumonia is associated with an increased risk of failing extubation in infants with PRS. Prospective studies are needed to evaluate whether screening for postoperative pneumonia and evaluating airway resistance before extubation can reduce the risk of EF.
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