ArticleFrontiers in genetics2026
Ischemic stroke as an initial manifestation of Loeys-Dietz syndrome type 3 caused by the recurrent p.Arg287Trp variant in
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Loeys-Dietz syndrome type 3 (LDS3) is a rare autosomal dominant connective tissue disorder caused by pathogenic variants in Case presentation: We report a 32-year-old Chinese woman who presented with acute ischemic stroke involving the right occipital lobe and thalamus. Comprehensive vascular imaging revealed multiple arterial abnormalities, including aberrant right subclavian artery with aneurysmal dilatation, right vertebral artery aneurysmal dilatation with multisegmental stenosis, left vertebral artery multifocal segmental severe stenosis, and tortuous intracranial vessels Whole-exome sequencing identified a heterozygous pathogenic variant NM_005902.4:c.859C>T (p.Arg287Trp) in Conclusion: This case expands the phenotypic spectrum of LDS3, emphasizing that ischemic stroke may be an underrecognized initial presentation. Early genetic screening in young stroke patients with unusual vascular features may facilitate timely diagnosis and enable appropriate preventive interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.