ArticleEuropean journal of case reports in internal medicine2026
A Cardiomyopathy to Remember: A Case Report of Desmoplakin Cardiomyopathy.
Article in European journal of case reports in internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Arrhythmogenic cardiomyopathies are an under-investigated common cause for myocardial infarction with no obstructive coronary artery disease. Case description: A 56-year-old male presented with myocardial infarction with no obstructive coronary artery disease in three different occasions. His transthoracic echocardiography showed dropped left ventricle function in the last presentation. This was further investigated by cardiac magnetic resonance imaging which showed distinguishable pattern of myocardial fibrosis. He had primary prevention with an implantable cardioverter-defibrillator. He tested positive for pathological variant for the desmoplakin (DSP) gene. Conclusion: Recurrent myocardial injury left ventricular fibrosis, and frequent premature ventricular contractions should always raise the suspicion of DSP cardiomyopathy. LEARNING POINTS: Recurrent episodes of myocardial infarction with non-obstructive coronary artery disease should raise the suspicion of desmoplakin cardiomyopathy.Cardiac magnetic resonance imaging is the gold standard imaging tool for diagnosis.No consensus regarding risk assessment however primary prevention towards ventricular arrhythmias needs to be considered.
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