ArticleNeuropsychiatric disease and treatment2026
Peripheral Nerve Conduction in Alzheimer's vs. Late-Life Depression: A Comparative Study.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Alzheimer's disease (AD) and late-life depression (LLD) patients both exhibit peripheral motor nerve conduction impairments, but with distinct patterns, highlighting divergent neurophysiological mechanisms in these aging-related disorders. Objective: To compare peripheral nerve conduction function among normal cognition (NC), older adults with AD, and LLD. Methods: All the participants were enrolled and assigned to AD, LLD and aged-matched NC controls (all ≥60 years, n=60, respectively). Sensory conduction of the median and sural nerves, and motor conduction of the median and common peroneal nerves, were assessed. Key parameters included latency, amplitude, and conduction velocity. Group differences were analyzed after adjusting for gender, age, education, height, and comorbid medical conditions. Results: By controlling gender, age, height, education level, and somatic diseases with inter-group differences, compared with NC group, the median nerve motor conduction in AD group showed prolonged proximal latency (3.21 vs. 3.65 ms, Conclusion: Both AD and LLD groups were associated with peripheral motor neuropathy, but the pattern of impairment differs. AD is marked by generalized conduction slowing, while LLD shows more severe latency delays and amplitude loss, suggesting distinct pathophysiological pathways. These findings provide new insights into the peripheral nervous system's involvement in age-related neurocognitive and mood disorders.
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