ArticleCureus2026
Double Diagnostic Dilemma in Metaplastic Breast Carcinoma.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metaplastic breast carcinoma is a rare and aggressive subtype of breast cancer. It is characterized by the differentiation of epithelial cells into mesenchymal components and often presents as a triple-negative phenotype. Its varied histomorphology can resemble sarcoma or lymphoma, making diagnosis difficult. We will be discussing a case of a 50-year-old woman with a right breast mass and multiple fluorodeoxyglucose (FDG)-avid splenic lesions on PET/CT, which initially suggested a metastatic disease or a disseminated lymphoma. Histopathology of the breast specimen revealed a metaplastic carcinoma with pleomorphic and spindle cell features. The splenic biopsy showed non-tuberculous granulomatous inflammation. This case highlights a diagnostic challenge involving both histological similarities and imaging pitfalls. It emphasizes the importance of tissue diagnosis in FDG-avid lesions to prevent over-staging.
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