ArticleMedComm2026
Hepatic Arterial Infusion Chemotherapy plus either Toripalimab or Sorafenib as First-line Therapy for Locally Advanced Hepatocellular Carcinoma: A Non-comparative, Randomized Phase 2 Trial.
Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04135690 (Hepatic Arterial Infusion Chemotherapy Plus Toripalimab Versus Hepatic Arterial Infusion Chemotherapy Plus Sorafenib for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus), which is not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hepatic Arterial Infusion Chemotherapy Plus Toripalimab Versus Hepatic Arterial Infusion Chemotherapy Plus Sorafenib for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: a Non-comparative, Prospective, Randomized Trial
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Authors and funding
13 authors.
Funding
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Abstract
This study was designed to provide prospective evidence for the combination of hepatic arterial infusion chemotherapy (HAIC) and toripalimab, which had suggested encouraging antitumor activity and safety in advanced hepatocellular carcinoma (HCC) previously. This single-center, non-comparative, randomized phase II study (NCT04135690) recruited locally advanced HCC participants (1:1) to receive HAIC plus either toripalimab (TorHAIC) or sorafenib (SoraHAIC) per 3 weeks. The primary endpoint was the progression-free survival (PFS) rate at 6 months. Seventy-two participants were randomly assigned to received TorHAIC (
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