Evidence map›Paper›PMID 42266152›Full record

ArticleThe Kobe journal of medical sciences2026

Geriatric Nutritional Risk Index Predicts Prognosis of Elderly Gastric Cancer Patients After Non-Curative Endoscopic Treatment.

Hitoshi Harada, Shingo Kanaji, Yutaka Sugita, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa and 6 more

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Article in The Kobe journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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16 authors.

Hitoshi HaradaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Shingo KanajiDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yutaka SugitaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Taro IkedaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yasufumi KoterazawaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Tomoaki AokiDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yasunori OtowaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Naoki UrakawaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Hironobu GotoDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroshi HasegawaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Toshitatsu TakaoDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Masashi YamamotoNinokiri Yamamoto Clinic, Osaka, Japan.
Kimihiro YamashitaDivision of Analytical Biomedical Sciences, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Takeru MatsudaDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yuzo KodamaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoshihiro KakejiDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Additional gastrectomy is usually performed after endoscopic submucosal dissection (ESD) for early gastric cancer diagnosed as "non-curative" according to the Japanese guidelines. However, the prognostic benefit of additional gastrectomy for the elderly with non-curative ESD is still debatable. The Geriatric Nutritional Risk Index (GNRI) is known as a prognostic value in elderly patients. This study aimed to clarify the advantages of GNRI as a prognostic indicator for elderly gastric cancer patients with non-curative ESD. A total of 120 elderly patients who underwent ESD for gastric cancer and diagnosed as non-curative resection according to the Japanese guidelines were retrospectively selected from the database of the Kobe University Hospital between January 2008 and March 2020. Their general condition, risk of lymph node metastasis, and nutritional status were evaluated retrospectively, and prognostic analysis was performed. After non-curative ESD, 48 patients underwent additional gastrectomy with lymph node dissection, and 72 patients were followed up with no additional treatment. In the follow-up group, patients with a high risk of lymph node metastasis had a significantly poorer prognosis. However, in the prognostic analysis of 120 cases, additional gastrectomy or follow-up were not independent prognostic factors. In the analysis of the additional gastrectomy group only, major nutrition-related risk of postoperative GNRI was an independent prognostic factor (95% CI: 0.01-0.25, P < 0.001). In elderly, the GNRI may be helpful as a prognostic indicator. Especially for elderly patients with poor nutritional status, additional gastrectomy might be considered only in cases of high risk of recurrence after non-curative ESD.

Indexed as

Endoscopic Mucosal ResectionGeriatric AssessmentNutritional StatusNutrition AssessmentStomach NeoplasmsAgedAged, 80 and overFemaleGastrectomyHumansLymphatic MetastasisLymph Node ExcisionMalePrognosisRetrospective StudiesElderlyEndoscopic submucosal dissectionGastrectomyGastric cancerNutritional risk index

Identifiers

PMID42266152
PMCPMC13286065

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